BRD7552

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

BRD7552 是转录因子 PDX1 的诱导剂，可增加胰岛素表达。 BRD7552 增加小鼠 αTC 细胞中的 PDX1 表达，但不增加 βTC 细胞中的 PDX1 表达。

BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression. BRD7552 increases PDX1 expression in mouse αTC cells but not βTC cells.

BRD7552 (0-5 μM; 5 days) induces a dose-dependent increase in PDX1 protein levels after BRD7552 treatment in PANC-1 cells.BRD7552 acts in a FOXA2-dependent manner to increase PDX1 expression in human ductal cells. Nine-day treatment of PANC-1 cells with BRD7552 (0-10 μM) causes a dose-dependent increase in insulin mRNA expression. BRD7552 induces insulin expression in PANC-1 cells. BRD7552 increases H3 acetylation and H3K4me3 and decreases H3K9me3, results that are consistent with transcriptional activation of PDX1. The epigenetic changes induced by BRD7552 are consistent with transcriptional activation, and BRD7552 acts in a FOXA2-dependent manner. Western Blot Analysis Cell Line:PANC-1 cells Concentration:1.25, 2.5, 5 μM Incubation Time:5 days Result:Induced a dose-dependent increase in PDX1 protein levels.

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Others

Other Targets

PDX1

Endocrinology

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1137359-47-7

711.63

C33H33N3O15

>98% (HPLC)

DMSO : ≥ 38 mg/mL 53.40 mM

CCOC(=O)c1ccc(cc1)NC(=O)O[C@@H]1[C@H](O[C@@H]([C@@H]([C@H]1OC(=O)Nc1cc2c(cc1)OCO2)OC(=O)Nc1cc2c(cc1)OCO2)OC)CO

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(-20℃)

With Ice Pack

≥ 2 years