FIN56 ( FIN56 | FIN-56 | FIN 56 )

产品货号. M17139 CAS No. 1083162-61-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

FIN56
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

FIN56 是铁死亡的特异性诱导剂。
产品描述

FIN56 is a specific inducer of ferroptosis.
体外实验

FIN56 (5 μM) can trigger ferroptosis by inhibition of glutathione peroxidase 4 (GPX4).FIN56 (5 μM, 10 hours) depletes GPX4 protein in HT-1080 cells.Cell Viability Assay Cell Line:TP53+/+ and TP53-/- HCT116 cells Concentration:5 μM Incubation Time:Result:Triggered ferroptosis.Western Blot Analysis Cell Line:HT-1080 cells Concentration:5 μM Incubation Time:10 hours Result:Caused a large decrease in the abundance of GPX4 at the protein level.
体内实验

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同义词

FIN56 | FIN-56 | FIN 56
通路

Others
靶点

Other Targets
受体

Others
研究领域

Metabolic Disease
适应症

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CAS Number

1083162-61-1
分子量

517.66
分子式

C25H31N3O5S2
纯度

>98% (HPLC)
溶解度

DMSO : ≥ 100 mg/mL 193.18 mM H2O : < 0.1 mg/mL
SMILES

C1CCC(CC1)NS(=O)(=O)C2=CC3=C(C=C2)C4=C(C3=NO)C=C(C=C4)S(=O)(=O)NC5CCCCC5
化学全称

N2,N7-Dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide

1. Shimada K, et al. Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis. Nat Chem Biol. 2016 Jul;12(7):497-503.

计算器

产品手册

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