AC-264613 ( AC-264613 | AC 264613 | AC264613 )

产品货号. M17128 CAS No. 1051487-82-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

AC-264613
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

AC-264613 是 GPCR 蛋白酶激活受体 2 (PAR2) 的激动剂。
产品描述

AC-264613 is the first agonist of the G-protein-coupled receptor (GPCR) protease activated receptor 2 (PAR2). AC-264613 suppresses interferon regulatory factor 5 and decreases interleukin-12p40 production by lipopolysaccharide-stimulated macrophages. AC-264613 activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays, with potencies ranging from 30 to 100 nM.
体外实验

AC-264613 (10 μM; for 6 hours) causes a decrease of IRF5 expression and also significantly reduces p53 protein expression in macrophages. Western Blot Analysis Cell Line:Granulocyte-macrophage colony-stimulating factor (GM-CSF)-dependent macrophages Concentration:10 μM Incubation Time:6 hours Result:Significantly decreased IRF5 expression and reduced p53 protein levels.
体内实验

AC-264613 exhibits moderate elimination half-live (T1/2=2.5±2.0 h) following i.p. administration (10 mg/kg) in male Sprague-Dawley rats.
同义词

AC-264613 | AC 264613 | AC264613
通路

Others
靶点

Other Targets
受体

PAR-2
研究领域

——
适应症

——

CAS Number

1051487-82-1
分子量

400.28
分子式

C19H18BrN3O2
纯度

>98% (HPLC)
溶解度

——
SMILES

O=C([C@H]1C(=O)NC[C@@H]1c1ccccc1)N/N=C(/c1cccc(Br)c1)\C
化学全称

(3R,?4S)?-?rel-2-?Oxo-?4-?phenyl-?3-?pyrrolidinecarboxyli?c acid 2-?[1-?(3-?bromophenyl)?ethylidene]?hydrazide

1.Cosimi E, et al. Stereoselective Synthesis of α-Fluoro-γ-nitro Thioesters under Organocatalytic Conditions. Org Lett. 2016 Dec 2;18(23):6014-6017

计算器

产品手册

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