NTCP binder peptide WD1 ( —— )

产品货号. M17088 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

NTCP binder peptide WD1
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

NTCP 结合肽 WD1 是一种大环肽，通过靶向 HBV 细胞表面受体，成为 HBV 进入细胞的泛基因型抑制剂。
产品描述

NTCP binder peptide WD1 is a macrocyclic peptide, pan-genotypic inhibitor of HBV cellular entry via targeting the cell-surface receptor for HBV, sodium taurocholate cotransporting polypeptide (NTCP, Kd=15 nM), reduces HBs antigen levels in culture supernatants; also inhibits cellular entry by the related hepatitis D virus (HDV), and is active against diverse strains of HBV (including clinically relevant nucleos(t)ide analog-resistant and vaccine escaping strains); exhibitsno inhibition of NTCP-mediated bile acid uptake in contrast to other NTCP-binding HBV entry inhibitors.
体外实验

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体内实验

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同义词

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通路

Microbiology/Virology
靶点

HBV
受体

HBV
研究领域

——
适应症

——

CAS Number

——
分子量

1917.216
分子式

C95H125N19O22S
纯度

>98% (HPLC)
溶解度

——
SMILES

——
化学全称

Cyclo-s-Ac-d-Tyr-Phe-Ile-Ile-ValMe-Gly(Me)-Thr-Trp-Thr-Trp-Thr-Trp-Ser-Cys-Thr-NH2

1. Passioura T, et al. Cell Chem Biol. 2018 Jul 19;25(7):906-915.e5.

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