SJB3-019A ( —— )

产品货号. M17002 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

SJB3-019A
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

一种新型有效的泛素特异性蛋白酶 USP1 抑制剂，IC50 为 78.1 nM。
产品描述

A novel potent ubiquitin-specific protease USP1 inhibitor with IC50 of 78.1 nM, 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells; also increases the levels of Ub-FANCD2 and Ub-PCNA, and decreases the HR activity; triggers apoptosis in multiple myeloma cells via activation of caspase-3/8/9, degrades USP1 and downstream inhibitor of DNA-binding proteins as well as inhibits DNA repair via blockade of Fanconi anemia pathway and homologous recombination; downregulates multiple myeloma stem cell Notch-1, Notch-2, SOX-4, and SOX-2, and induces generation of more mature and differentiated plasma cells.
体外实验

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体内实验

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同义词

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通路

Proteasome/Ubiquitin
靶点

DUB
受体

DUB
研究领域

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适应症

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1. Mistry H, et al. Mol Cancer Ther. 2013 Dec;12(12):2651-62. 2. Das DS, et al. Clin Cancer Res. 2017 Mar 7. doi: 10.1158/1078-0432.CCR-16-2692.

计算器

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