WJ-39 is an orally active aldose reductase (AR) inhibitor that ameliorates renal lesions in diabetic nephropathy through activation of Nrf2 signaling, and may be used to ameliorate renal insufficiency and fibrosis.WJ-39 inhibits oxidative stress and inhibits the activation of the inflammatory vesicle of the oligomerization structural domain-like receptor family, pyrin structural domain 3 (NLRP3).

舒林酸砜是非甾体类抗炎药舒林酸的代谢产物。 Sulindac sulfone 是一种醛糖还原酶抑制剂 (IC50 =367 nM)。

除虫脲是一种苯甲酰脲类杀虫剂，被发现是小鼠黑色素瘤细胞中黑色素体合成的有效抑制剂。