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首页- Products - Others - Other Targets - Eflornithine hydrochloride Monohydrate

Eflornithine hydrochloride Monohydrate

CAS No. 96020-91-6

Eflornithine hydrochloride Monohydrate ( DFMO | Eflornithine )

产品货号. M16851 CAS No. 96020-91-6

盐酸依氟鸟氨酸水合物（DFMO；MDL-71782）是一种可有效治疗面部多毛症的化合物。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
10MG ￥138 有现货
25MG ￥197 有现货
50MG ￥272 有现货
100MG ￥374 有现货
500MG ￥1107 有现货
1G 获取报价 有现货
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生物学信息

  • 产品名称
    Eflornithine hydrochloride Monohydrate
  • 注意事项
    本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
  • 产品简述
    盐酸依氟鸟氨酸水合物（DFMO；MDL-71782）是一种可有效治疗面部多毛症的化合物。
  • 产品描述
    Eflornithine hydrochloride, hydrate (DFMO; MDL-71782) is a drug found to be effective in the treatment of facial hirsutism.(In Vivo):Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases. In subjects with excessive, unwanted facial hair, eflornithine 15% cream is superior to placebo in reducing hair growth. After 24 weeks' treatment, 58% of eflornithine and 34% of placebo subjects have at least some improvement in facial hirsutism. The hair growth inhibitory activity of eflornithine is significantly enhanced when the eflornithine cream is applied onto a mouse skin area pretreated with microneedles. Treatment of coarctation hypertensive rats with eflornithine results in a normalization of the contractile intensity to KCI and norepinephrine and relaxations to acetylcholine by 14 days of hypertension.
  • 体外实验
    ——
  • 体内实验
    Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases. In subjects with excessive, unwanted facial hair, eflornithine 15% cream is superior to placebo in reducing hair growth. After 24 weeks' treatment, 58% of eflornithine and 34% of placebo subjects have at least some improvement in facial hirsutism. The hair growth inhibitory activity of eflornithine is significantly enhanced when the eflornithine cream is applied onto a mouse skin area pretreated with microneedles. Treatment of coarctation hypertensive rats with eflornithine results in a normalization of the contractile intensity to KCI and norepinephrine and relaxations to acetylcholine by 14 days of hypertension.
  • 同义词
    DFMO | Eflornithine
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Others
  • 研究领域
    Other Indications
  • 适应症
    ——

化学信息

  • CAS Number
    96020-91-6
  • 分子量
    236.64
  • 分子式
    C6H15ClF2N2O3
  • 纯度
    >98% (HPLC)
  • 溶解度
    Soluble in DMSO
  • SMILES
    O.Cl.NCCCC(N)(C(F)F)C(O)=O
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Mohammed A, et al. Y Prev Res (Phila). 2014 Dec;7(12):1198-209.
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