KKL-10

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

KKL-10 是一种细菌核糖体救援的小分子抑制剂，对液体培养中生长的细菌表现出广谱抗菌活性。

KKL-10 is a small-molecule inhibitor of bacterial ribosome rescue that exhibits broad-spectrum antimicrobial activity against bacteria grown in liquid culture; exhibits exceptional antimicrobial activity against both attenuated (LVS) and fully virulent strains of F. tularensis (Schu S4) in vitro with MIC of 0.12 and 0.48 ug/mL, respectively; arrests intracellular growth of F. tularensis during all stages of infection, does not affect macrophage viability or function.

The ribosome rescue inhibitor KKL-10 exhibits exceptional antimicrobial activity against both attenuated and fully virulent strains of F. tularensis. The minimum inhibitory concentration (MIC) against F. tularensis strain LVS and Schu S4 are 0.12 and 0.48 μg/mL, respectively. KKL-10 arrests intracellular growth of F. tularensis during all stages of infection. KKL-10 does not affect macrophage viability or function. KKL-10 produces cytotoxic effects of less than 5% at concentrations up to 17.5 μg/mL. The combination of IFN-γ stimulation and KKL-10 activity results in a reduction of the bacterial load by >99.9%. KKL-10 is also able to inhibit growth of F. tularensis inside eukaryotic cells and show no toxicity to HepG2 cells.

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KKL10

GPCR/G Protein

Antibacterial

ribosomerescue

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952849-76-2

364.217

4H10BrN3O2S

>98% (HPLC)

DMSO: Soluble （ < 1 mg/ml refers to the product slightly soluble or insoluble )

O=C(C1=CC=C(Br)S1)NC2=NN=C(C3=CC=C(C)C=C3)O2

5-Bromo-N-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]-2-thiophenecarboxamide

(-20℃)

With Ice Pack

≥ 2 years