LMD-009

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

LMD-009 (LMD 009, LMD009) 是一种有效的、选择性的非肽 CCR8 激动剂。

LMD-009 (LMD 009, LMD009) is a potent, selective, nonpeptide CCR8 agonist that stimulates CCR8-mediated chemotaxis, inositol phosphate accumulation and calcium release with EC50 of 11-87 nM; displays no activity against other chemokine receptors.

Cell Viability Assay Cell Line:COS-7 cells Concentration:0-20 nM Incubation Time:90 min Result:Stimulated inositol phosphate accumulation in COS-7 cells expressing the human CCR8 receptor with an EC50 value of 11 nM. Inhibited none of the receptors of other human chemokine receptors.Cell Viability Assay Cell Line:Chinese hamster ovary cells Concentration:0-100 nM Incubation Time:1 hour Result:Regulated calcium release in Chinese hamster ovary cells with an EC50 value 87 nM.Cell Migration Assay Cell Line:Lymphocyte L1.2 cells.Concentration:0.1 nM- 100 μM Incubation Time:40 min Result:Exhibited an Ki value of 66 nM with L1.2 cells and specifically bound 125I-CCL1.

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LMD 009 | LMD009

GPCR/G Protein

Chemokine Receptor

Chemokine Receptor

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950195-51-4

471.601

C29H33N3O3

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (530.12 mM)

O=C1NCN(CCC2=CC=CC=C2)C13CCN(CC4=CC=CC(OC5=CC=CC=C5OC)=C4)CC3

8-[3-(2-methoxyphenoxy)benzyl]-1-phenethyl-1,3,8-triaza-spiro[4.5]decan-4-one

(-20℃)

With Ice Pack

≥ 2 years