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Zatebradine hydrochloride
CAS No. 91940-87-3
Zatebradine hydrochloride ( UL-FS-49 | UL-FS-49CL )
产品货号. M16598 CAS No. 91940-87-3
Zatebradine Hydrochloride (UL-FS49) 是一种强效的超极化激活环核苷酸门控 (HCN) 通道阻断剂（拮抗剂）。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥428 | 有现货 |
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| 10MG | ￥747 | 有现货 |
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| 25MG | ￥1535 | 有现货 |
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| 50MG | ￥2213 | 有现货 |
|
| 100MG | ￥3141 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥473 | 有现货 |
|
生物学信息
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产品名称Zatebradine hydrochloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Zatebradine Hydrochloride (UL-FS49) 是一种强效的超极化激活环核苷酸门控 (HCN) 通道阻断剂（拮抗剂）。
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产品描述Zatebradine hydrochloride (UL-FS49) is a potent blocker (antagonist) of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel, a specific bradycardic agent; blocks cardiac pacemaker current (If), decreases the rate of spontaneously beating guinea-pig atria with EC50 of 0.030 ug/mL.Heart Failure Discontinued.
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体外实验The use-dependent blockade by Zatebradine of the cardiac pacemaker current from rabbit sino-atrial node cells has an apparent Kd of 480 nM.
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体内实验Zatebradine (0-20 mg/kg; intraperitoneal injection; for 30 minutes; male C57/Bl6-mice) reduces the heart rate dose-dependently from 600 to 200 bpm with ED50 value of 1.8 mg/kg and induces increasing arrhythmia. Animal Model:Male C57/Bl6-mice Dosage:0 mg/kg, 0.1 mg/kg, 1 mg/kg, 10 mg/kg, 20 mg/kg Administration:Intraperitoneal injection; for 30 minutes Result:Observed acute blood glucose reduction, dose-dependently reduced glycated hemoglobin, significantly prevented the decrease of IRI levels at doses of 3 and 10 mg/kg, and no difference in food intake or body weight.
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同义词UL-FS-49 | UL-FS-49CL
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通路Membrane Transporter/Ion Channel
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靶点HCN Channel
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受体HCN Channel
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研究领域Cardiovascular Disease
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适应症——
化学信息
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CAS Number91940-87-3
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分子量493.0354
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分子式C26H37ClN2O5
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESO=C1CC2=CC(OC)=C(OC)C=C2CCN1CCCN(CCC3=CC=C(OC)C(OC)=C3)C.[H]Cl
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化学全称2H-3-Benzazepin-2-one, 3-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-, hydrochloride (1:1)
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Van Bogaert PP, et al. Eur J Pharmacol. 2003 Oct 8;478(2-3):161-71.
2. McGovern AE, et al. Br J Pharmacol. 2014 Aug;171(15):3633-50.
3. Gill CH, et al. Br J Pharmacol. 2004 Oct;143(3):411-21.
