BRPF1-IN-3 ( GSK-5959 | GSK 5959 | GSK5959. )

产品货号. M16481 CAS No. 901245-65-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

BRPF1-IN-3
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

BRPF1-IN-3 是一种有效的、选择性的、膜可渗透的 BRPF1 bromodomain 抑制剂，pIC50 为 7.1。
产品描述

BRPF1-IN-3 is a potent, selective, membrane permeable BRPF1 bromodomain inhibitor with pIC50 of 7.1; shows 100- and >1000-fold selectivity over BRPF2 and BRPF3, respectively; exhibits an IC50 of 0.98 uM in cellular protein interaction assay (displacement of NanoLuc-tagged BRPF1 bromodomain from Halo-tagged histone H3.3).
体外实验

GSK-5959 (3a) also displays selectivity over the closely related family members, BRPF2 (100-fold) and BRPF3 (>1000-fold).GSK-5959 (3a) exhibits an EC50 = 0.98 μM) in cellular NanoBRET assay.GSK-5959 has no effect on TRIM24 SUMOylation.
体内实验

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同义词

GSK-5959 | GSK 5959 | GSK5959.
通路

Chromatin/Epigenetic
靶点

Bromodomain
受体

BRPF1
研究领域

Other Indications
适应症

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CAS Number

901245-65-6
分子量

394.475
分子式

C22H26N4O3
纯度

>98% (HPLC)
溶解度

DMSO: 10 mM （ < 1 mg/ml refers to the product slightly soluble or insoluble )
SMILES

O=C(NC1=C(N2CCCCC2)C=C(N3C)C(N(C)C3=O)=C1)C4=CC=CC=C4OC
化学全称

N-(1,3-dimethyl-2-oxo-6-(piperidin-1-yl)-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-2-methoxybenzamide