Verdiperstat

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Verdiperstat (AZD-3241) 是一种有效、选择性、可逆、口服活性髓过氧化物酶 (MPO) 抑制剂，IC50 为 630 nM，选择性是甲状腺过氧化物酶 (TPO) 的 14 倍以上。

Verdiperstat (AZD-3241) is a potent, selective, reversible, orally active myeloperoxidase (MPO) inhibitor with IC50 of 630 nM, >14-fold selectivity over thyroid peroxidase (TPO); inhibits PMA stimulate neutrophils and zymosan stimulated whole blood with IC50 of 80 nM, efficiently inhibits MPO activity in vivo during acute peritonitis in rats and has consistently shown neuroprotective efficacy in MPTP-lesioned mice, a model of Parkinson’s Disease; also demonstrates significant neuroprotection in MSA mouse model.Spinal Muscular Atrophy (SMA) Phase 2 Discontinued(In Vitro):Verdiperstat (AZD3241) is a myeloperoxidase (MPO) inhibitor, with an IC50 of 630 nM, and is used in the research of neurodegenerative brain disorders. Verdiperstat (AZD3241) selectively and irreversibly inhibits myeloperoxidase, and may involves reduction of oxidative stress leading to reduction of sustained neuroinflammation.

Verdiperstat (AZD3241) is a myeloperoxidase (MPO) inhibitor, with an IC50 of 630 nM, and is used in the research of neurodegenerative brain disorders. Verdiperstat (AZD3241) selectively and irreversibly inhibits myeloperoxidase, and may involves reduction of oxidative stress leading to reduction of sustained neuroinflammation.

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AZD-3241

Others

Other Targets

Other Targets

Neurological Disease

Spinal Muscular Atrophy(SMA)

890655-80-8

253.32

C11H15N3O2S

>98% (HPLC)

DMSO : 150 mg/mL 592.14 mM

O=C(N1)C(NC=C2)=C2N(CCOC(C)C)C1=S

1-[2-(propan-2-yloxy)ethyl]-2-sulfanylidene-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-one

(-20℃)

With Ice Pack

≥ 2 years