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CMP-5
CAS No. 880813-42-3
CMP-5 ( PRMT5-IN-5 )
产品货号. M16388 CAS No. 880813-42-3
CMP-5 (PRMT5-IN-5) 是一种一流的小分子 PRMT5 特异性抑制剂，可阻止 EBV 驱动的 B 淋巴细胞转化和存活。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥785 | 有现货 |
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| 10MG | ￥1254 | 有现货 |
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| 25MG | ￥1841 | 有现货 |
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| 50MG | ￥3125 | 有现货 |
|
| 100MG | ￥4302 | 有现货 |
|
| 200MG | ￥5994 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥1036 | 有现货 |
|
生物学信息
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产品名称CMP-5
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述CMP-5 (PRMT5-IN-5) 是一种一流的小分子 PRMT5 特异性抑制剂，可阻止 EBV 驱动的 B 淋巴细胞转化和存活。
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产品描述CMP-5 (PRMT5-IN-5)is a first-in-class, small-molecule PRMT5-specific inhibitor that blocks EBV-driven B-lymphocyte transformation and survival, without effect on normal B cells; displays no activity against other type I (PRMT1 and PRMT4) and type II (PRMT7) enzymes; inhibition of PRMT5 leads to lost recruitment of a PRMT5/p65/HDAC3-repressive complex on the miR96 promoter, restored miR96 expression, and PRMT5 downregulation.
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体外实验Western Blot Analysis Cell Line:60A cells?Concentration:40 μM Incubation Time:24 hours Result:Inhibited p-BTK and pY(416)SRC protein level.Cell Viability Assay Cell Line:Human Th1 cells and Th2 cells Concentration:25 μM Incubation Time:24 hours Result:Inhibited mouse Th1 cell proliferation, but addition of IL-2 dose-dependently increased cell proliferation.
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体内实验——
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同义词PRMT5-IN-5
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通路Chromatin/Epigenetic
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靶点HMTase
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受体HMTase
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研究领域——
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适应症——
化学信息
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CAS Number880813-42-3
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分子量315.42
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分子式C21H21N3
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 125 mg/mL (396.31 mM)
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SMILESCCN1C2=C(C=C(C=C2)CNCC3=CC=CC=N3)C4=CC=CC=C41.Cl
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化学全称1-(9-Ethyl-9H-carbazol-3-yl)-N-(2-pyridinylmethyl)methanamine
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Alinari L, et al. Blood. 2015 Apr 16;125(16):2530-43.
