Isosorbide dinitrate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

用于治疗心绞痛的血管扩张剂。其作用与硝酸甘油相似，但起效较慢。

A vasodilator used in the treatment of ANGINA PECTORIS. Its actions are similar to NITROGLYCERIN but with a slower onset of action. (In Vivo):Isosorbide dinitrate (3 mg/kg; intratracheal; for 13 days) improves pulmonary artery pressure and ventricular remodeling in a rat model of heart failure following myocardial infarction.Isosorbide dinitrate postconditioning exhibits a cardioprotective effect against rat myocardial ischemia-reperfusion injury in vivo.

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Animal Model:5–6 weeks old male juvenile Sprague-Dawley rats (200–250 g)Dosage:3 mg/kg Administration:Intratracheal; for 13 days following coronary ligation Result:Reduced MI size and alleviated left and right ventricular remodeling following MI.

NSC 80038

Others

Other Targets

NPR1

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87-33-2

236.14

C6H8N2O8

>98% (HPLC)

Soluble in Water

O=[N+]([O-])O[C@H]1[C@@H](OC[C@H]2O[N+]([O-])=O)[C@@H]2OC1

(3R,3aS,6R,6aS)-hexahydrofuro[3,2-b]furan-3,6-diyl dinitrate

(-20℃)

With Ice Pack

≥ 2 years