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CX-3543
CAS No. 865311-47-3
CX-3543 ( Quarfloxin | Itarnafloxin )
产品货号. M16281 CAS No. 865311-47-3
CX-3543（Quarfloxin、Itarnafloxin）是一种小分子核仁靶向剂，可选择性破坏核仁中的核仁蛋白/rDNA G-四联体复合物。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1102 | 有现货 |
|
| 10MG | ￥1758 | 有现货 |
|
| 25MG | ￥3432 | 有现货 |
|
| 50MG | ￥4920 | 有现货 |
|
| 100MG | ￥6525 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥1549 | 有现货 |
|
生物学信息
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产品名称CX-3543
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述CX-3543（Quarfloxin、Itarnafloxin）是一种小分子核仁靶向剂，可选择性破坏核仁中的核仁蛋白/rDNA G-四联体复合物。
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产品描述CX-3543 (Quarfloxin, Itarnafloxin) is a small molecule nucleolus-targeting agent that selectively disrupts nucleolin/rDNA G-quadruplex complexes in the nucleolus, thereby inhibiting Pol I transcription and inducing apoptosis in cancer cells.Blood Cancer Phase 2 Discontinued.
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体外实验Quarfloxin (CX-3543) effectively inhibits the growth of neuroblastoma cells in vitro. MNA (or high c-Myc) and wt-TP53 cell lines are found to be more sensitive to Quarfloxin. Quarfloxin and induces DNA damage, p53 signaling, cell death, and cell cycle arrest in neuroblastoma cell lines.Solution in vitro: Quarfloxin is suspended in DMSO to a stock of 10 mM.
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体内实验——
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同义词Quarfloxin | Itarnafloxin
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通路Cell Cycle/DNA Damage
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靶点DNA/RNA Synthesis
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受体DNA/RNA Synthesis
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研究领域Cancer
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适应症Blood cancer
化学信息
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CAS Number865311-47-3
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分子量604.67
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分子式C35H33FN6O3
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 5 mg/mL (8.27 mM)
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SMILESO=C(C1=CN2C3=C(C(N4C[C@H](C5=NC=CN=C5)CC4)=C(F)C=C3C1=O)OC6=CC7=CC=CC=C7C=C26)NCC[C@H]8N(C)CCC8
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化学全称5-fluoro-N-(2-((S)-1-methylpyrrolidin-2-yl)ethyl)-3-oxo-6-((R)-3-(pyrazin-2-yl)pyrrolidin-1-yl)-3H-benzo[b]pyrido[3,2,1-kl]phenoxazine-2-carboxamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Drygin D, et al. Cancer Res. 2009 Oct 1;69(19):7653-61.
2. Stokes JM, et al. Nat Chem Biol. 2015 Dec;11(12):924-32.
3. Xu H, et al. Nat Commun. 2017 Feb 17;8:14432.
产品手册
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