MMAF-OMe

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种抗有丝分裂剂，通过阻断微管蛋白的聚合来抑制细胞分裂。

An antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin. It is linked to an antibody with high affinity to structures on cancer cells, causing MMAF to accumulate in such cells; an ADC payload.

2.5F-Fc and 2.5F-Fc-MMAF have similar IC50?values (6.9±1.1 vs. 8.3±1.3 nM, respectively), indicating that MMAF conjugation has negligible impact on integrin-binding affinity.

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Monomethyl auristatin F methyl ester

Antibody Drug Conjugates (ADC)

ADC Cytotoxin

ADC Cytotoxin

Cancer

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863971-12-4

745.9887

C40H67N5O8

>98% (HPLC)

DMSO

CCC(C)C(C(CC(=O)N1CCCC1C(C(C)C(=O)NC(CC2=CC=CC=C2)C(=O)OC)OC)OC)N(C)C(=O)C(C(C)C)NC(=O)C(C(C)C)NC

L-Phenylalanine, N-methyl-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(αR,βR,2S)-β-methoxy-α-methyl-2-pyrrolidinepropanoyl-, methyl ester

(-20℃)

With Ice Pack

≥ 2 years