Ropivacaine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

罗哌卡因是一种属于氨基酰胺类的局部麻醉药。

Ropivacaine is a local anaesthetic drug belonging to the amino amide group. The name ropivacaine refers to both the racemate and the marketed S-enantiomer. Ropivacaine hydrochloride is commonly marketed by AstraZeneca under the trade name Naropin. (In Vivo):Epidural administration of Ropivacaine effectively blocks neuropathic pain (both mechanical allodynia and heat hyperalgesia) without induction of analgesic tolerance and significantly delays the development of neuropathic pain produced by peripheral nerve injury.Ropivacaine inhibits pressure-induced increases in filtration coefficient (Kf) without affecting pulmonary artery pressure (Ppa), pulmonary capillary pressures (Ppc), and zonal characteristics (ZC).Ropivacaine prevents pressure-induced lung edema and associated hyperpermeability as evidence by maintaining PaO2, lung wet-to-dry ratio and plasma volume in levels similar to sham rats.Ropivacaine inhibits pressure-induced NO production as evidenced by decreased lung nitro-tyrosine content when compared to hypertensive lungs.

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Animal Model:Adult Sprague-Dawley rats (300–400g) Dosage:1 μM Administration:Infusion (added to the perfusate reservoir)Result:Attenuated pressure-dependent increases in filtration coefficient (Kf).

Ropivacaine | Narop | Noropine | Ropivacaina | Ropivacainum | LEA 103

Membrane Transporter/Ion Channel

Sodium Channel

Sodium Channel

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84057-95-4

274.4

C17H26N2O

>98% (HPLC)

Water: 57.6 mg/L

CCCN1CCCC[C@H]1C(Nc2c(C)cccc2C)=O

(S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide

(-20℃)

With Ice Pack

≥ 2 years