Homatropine Methylbromide

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Homatropinemethylbromide 是一种季铵毒蕈碱乙酰胆碱受体拮抗剂，属于抗毒蕈碱化合物组。

Homatropine methylbromide is a quaternary ammonium muscarinic acetylcholine receptor antagonist belonging to the group of medicines called anti-muscarinics. Homatropine is used to treat duodenal or stomach ulcers or intestine problems. It can be used together with antacids or other medicine in the treatment of peptic ulcer. It may also be used to prevent nausea, vomiting, and motion sickness. (In Vitro):Homatropine methylbromide (Homatropine methobromide) (20 μM) alone produces a dose ratio of 259 in atrium from guinea-pigs. Homatropine methylbromide (Homatropine methobromide) (20 μM) produces a dose ratio of only 95.0 when combined with hexamethonium in atrium from guinea-pigs.(In Vivo):Pre-treatment with Homatropine methylbromide (Homatropine methobromide) (20 mg/kg) was comparable with atropine (10 mg/kg) in preventing lethality in this rat model of acute OC poisoning.

Homatropine methylbromide (Homatropine methobromide) (20 μM) alone produces a dose ratio of 259 in atrium from guinea-pigs. Homatropine methylbromide (Homatropine methobromide) (20 μM) produces a dose ratio of only 95.0 when combined with hexamethonium in atrium from guinea-pigs.

Pre-treatment with Homatropine methylbromide (Homatropine methobromide) (20 mg/kg) was comparable with atropine (10 mg/kg) in preventing lethality in this rat model of acute OC poisoning.

NSC 34399

Endocrinology/Hormones

AChR

mAChR (SHR-E)| mAChR (WKY-E)

Neurological Disease

——

80-49-9

370.29

C17H24BrNO3

>98% (HPLC)

Ethanol: 10 mg/mL (27.0 mM); Water: 74 mg/mL (199.84 mM); DMSO: 74 mg/mL (199.84 mM)

C[N+]1(C2CCC1CC(C2)OC(=O)C(C3=CC=CC=C3)O)C.[Br-]

(8,8-dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl) 2-hydroxy-2-phenylacetate;bromide

(-20℃)

With Ice Pack

≥ 2 years