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Arctigenin
CAS No. 7770-78-7
Arctigenin ( —— )
产品货号. M15933 CAS No. 7770-78-7
牛蒡甙元是一种在某些菊科植物中发现的木酚素； 它在玻璃中显示出抗病毒和抗癌作用。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | ￥513 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
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| 1G | 获取报价 | 有现货 |
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| 1 mL x 10 mM in DMSO | ￥181 | 有现货 |
|
生物学信息
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产品名称Arctigenin
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述牛蒡甙元是一种在某些菊科植物中发现的木酚素； 它在玻璃中显示出抗病毒和抗癌作用。
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产品描述Arctigenin is a lignan found in certain plants of the Asteraceae; it has shown antiviral and anticancer effects in glass; it is the aglycone of arctiin.(In Vitro):Arctigenin (0.01-1 μg/mL; 0.5-24 h) shows preferential cytotoxicity against the PANC-1 cell line under nutrient-deprived conditions in a concentration- and time-dependent manner.Arctigenin (0.01-1 μg/mL; 0.5-24 h) inhibits the survival of various cancer cell lines (ASPC-1, BXPC-3, Alexander, and PSN-1 cells) under nutrient-deprived conditions.Arctigenin (0.1-1 μg/mL; 24 h) completely inhibits Akt phosphorylation stimulated by glucose deprivation in PANC-1 cells.Arctigenin (5-25 μM) shows potent in vitro antiviral activities (IC50=2.9 μM) against influenza A virus.(In Vivo):Arctigenin (250 μg/mL; 0.2 mL; i.p. 6 times a week for 9 weeks) suppress the PANC-1 tumor growth in nude mice.Arctigenin (10 mg/kg; i.p. daily for 30 days) relieves experimental autoimmune encephalomyelitis (EAE) symptoms of mice.
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体外实验Arctigenin (0.01-1 μg/mL; 0.5-24 h) shows preferential cytotoxicity against the PANC-1 cell line under nutrient-deprived conditions in a concentration- and time-dependent manner.?Arctigenin (0.01-1 μg/mL; 0.5-24 h) inhibits the survival of various cancer cell lines (ASPC-1, BXPC-3, Alexander, and PSN-1 cells) under nutrient-deprived conditions.?Arctigenin (0.1-1 μg/mL; 24 h) completely inhibits Akt phosphorylation stimulated by glucose deprivation in PANC-1 cells.?Arctigenin (5-25 μM) shows potent in vitro antiviral activities (IC50=2.9 μM) against influenza A virus.
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体内实验Arctigenin (250 μg/mL; 0.2 mL; i.p. 6 times a week for 9 weeks) suppress the PANC-1 tumor growth in nude mice.Arctigenin (10 mg/kg; i.p. daily for 30 days) relieves experimental autoimmune encephalomyelitis (EAE) symptoms of mice. Animal Model:Female SPF/VAF BALB/cAn Ncrj-nu/nu mice were injected with PANC-1 cells Dosage:250 μg/mL, 0.2 mL Administration:I.p. 6 times a week for 9 weeks Result:Reduced the tumor weight and volume.
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同义词——
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通路Others
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靶点Other Targets
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受体Others
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研究领域Cancer
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适应症——
化学信息
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CAS Number7770-78-7
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分子量372.41
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分子式C21H24O6
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纯度>98% (HPLC)
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溶解度DMSO: 10 mM
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SMILESO=C1OC[C@H](CC2=CC=C(OC)C(OC)=C2)[C@H]1CC3=CC=C(O)C(OC)=C3
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化学全称(3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3- [(4-hydroxy-3-methoxyphenyl)methyl]-2-tetrahydrofuranone
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Wu X, et al. Biochem Pharmacol. 2015 Aug 15;96(4):323-36.
产品手册
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