ML406 ( ML406 | ML-406 | ML 406 )

产品货号. M15926 CAS No. 774589-47-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

ML406
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

ML406 是一种小分子 Mtb bioA（DAPA 合酶）酶抑制剂 (IC50=30 nM)，具有抗结核活性。
产品描述

ML406 is a small molecule Mtb bioA (DAPA synthase) enzyme inhibitor (IC50=30 nM) that shows anti-tubercular activity, dispalys >100-fold selectivity over bioD; exhibits WT M. tb (H37Rv) growth inhibition without biotin with an IC50 of 3.2 uM.
体外实验

ML406 inhibits WT Mycobacterium tuberculosis (Mtb) (H37Rv) growth inhibition with the IC50 of 3.2 μM. BioA is an enzyme involved in biotin biosynthesis in Mtb that may serve as lead compounds for drug development for tuberculosis (TB).
体内实验

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同义词

ML406 | ML-406 | ML 406
通路

GPCR/G Protein
靶点

Antibacterial
受体

Antibacterial
研究领域

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适应症

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1. Casalena D, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

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