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ICA-1
CAS No. 742038-81-9
ICA-1 ( —— )
产品货号. M15832 CAS No. 742038-81-9
ICA-1 是一种有效的、特异性的蛋白激酶 C-iota (PKC-ι) 抑制剂，IC50 为 0.1 uM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称ICA-1
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述ICA-1 是一种有效的、特异性的蛋白激酶 C-iota (PKC-ι) 抑制剂，IC50 为 0.1 uM。
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产品描述ICA-1 is a potent, specific inhibitor of Protein Kinase C-iota (PKC-ι) with IC50 of 0.1 uM, does not inhibit PKC-ζ, the closely related atypical PKC family member; potently inhibits the phosphorylation of Cdk7 by PKC-ι, inhibits PKC-ι/Cdk7/cdk2 cell signaling pathway and exhibits antiproliferative effects in neuroblastoma cells, also induces apoptosis; significantly reduces migration and melanoma cell invasion, downregulates TNF-α induced NF-κB translocation to the nucleus there by inducing apoptosis.
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体外实验——
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体内实验——
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同义词——
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通路Angiogenesis
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靶点PKC
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受体PKC
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研究领域——
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适应症——
化学信息
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CAS Number742038-81-9
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分子量336.241
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分子式C10H17N4O7P
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纯度>98% (HPLC)
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溶解度——
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SMILESC1C(C(C(C1N2C=NC(=C2N)C(=O)N)O)O)COP(=O)(O)O
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化学全称5-Amino-1-[(1R,2S,3R,4R)-2,3-dihydroxy-4-[(phosphonooxy)methyl]cyclopentyl]-1H-imidazole-4-carboxamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Pillai P, et al. Int J Biochem Cell Biol. 2011 May;43(5):784-94.
2. McCray AN, et al. Neurochem Res. 2014 Sep;39(9):1691-701.
3. Ratnayake WS, et al. Cell Adh Migr. 2018 May 21:1-17.
产品手册
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