Rifabutin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种半合成安沙霉素抗生素，具有有效的抗分枝杆菌特性。

A semisynthetic ansamycin antibiotic with potent antimycobacterial properties. Bacterial Infection Approved(In Vitro):Rifabutin is primarily bactericidal antibiotic drug used to treat tuberculosis. Its effect on bacteria is based on the DNA-dependent RNA polymerase blocking drug rifamycin S., a semi-synthetic derivative. It is effective, for example, in highly resistant mycobacteria, Gram-positive bacteria (and some are effective against Gram-negative bacteria), but also against Mycobacterium tuberculosis, M. leprae, and M. avium intracellulare. Rifabutin is an antibiotic; antitumor. Rifabutin interferes with HSP-90 molecular chaperone, enhances ubiquitination and protein degradation, and inactivates bacterial RNA polymerase.

Rifabutin is primarily bactericidal antibiotic drug used to treat tuberculosis. Its effect on bacteria is based on the DNA-dependent RNA polymerase blocking drug rifamycin S., a semi-synthetic derivative. It is effective, for example, in highly resistant mycobacteria, Gram-positive bacteria (and some are effective against Gram-negative bacteria), but also against Mycobacterium tuberculosis, M. leprae, and M. avium intracellulare. Rifabutin is an antibiotic; antitumor. Rifabutin interferes with HSP-90 molecular chaperone, enhances ubiquitination and protein degradation, and inactivates bacterial RNA polymerase.

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Ansamycin | LM-427

GPCR/G Protein

Antibacterial

Endoplasmin|HSP90|RNApolymerase

Infection

Bacterial Infection

72559-06-9

847.0047

C46H62N4O11

>98% (HPLC)

10 mM in DMSO

O=C1c2c(O)c(C)c3c(C4=O)c2C5=NC6(CCN(CC(C)C)CC6)NC5=C1NC(/C(C)=C/C=C/[C@@H]([C@H](O)[C@H]([C@@H](O)[C@H]([C@@H]([C@H](C)[C@@H](OC)/C=C/O[C@]4(O3)C)OC(C)=O)C)C)C)=O

Spiro[9,4-(epoxypentadeca[1,11,13]trienimino)-2H-furo[2',3':7,8]naphth[1,2-d]imidazole-2,4'-piperidine]-5,10,26(3H,9H)-trione, 16-(acetyloxy)-6,18,20-trihydroxy-14-methoxy-7,9,15,17,19,21,25-heptamethyl-1'-(2-methylpropyl)-, (9S,12E,14S,15R,16S,17R,18R,19

(-20℃)

With Ice Pack

≥ 2 years