Veratridine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Veratridine 是一种在 Veratrumand Schoenocaulon 中发现的苯甲酸酯-cevane。它激活钠通道，使钠通道保持开放时间比正常情况更长。

Veratridine is a benzoate-cevane found in veratrumand Schoenocaulon. It activates sodium channels to stay open longer than normal.

Cell Cytotoxicity Assay Cell Line:Neuro-2a cells Concentration:0.25 mM and 1 mM Incubation Time:24 hours Result:Caused around 100% cell mortality (0% cell viability).Cell Viability Assay Cell Line:Cultured mouse DRG neurons Concentration:0.001, 0.1, 1, 10, 30, and 100 μM Incubation Time:Result:Increased responding neurons number from a threshold of 1 μM in a concentration-dependent manner.

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Membrane Transporter/Ion Channel

Sodium Channel

Sodium Channel

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71-62-5

673.79

C36H51NO11

>98% (HPLC)

10 mM in DMSO

C[C@H]1CC[C@H]2[C@@]([C@]3([C@H](C[C@]4([C@@H]5CC[C@H]6[C@]7([C@]5(C[C@]4([C@@H]3CN2C1)O)O[C@@]6([C@H](CC7)OC(=O)C8=CC(=C(C=C8)OC)OC)O)C)O)O)O)(C)O

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(-20℃)

With Ice Pack

≥ 2 years