GO289 ( GO-289 | GO 289 )

产品货号. M15657 CAS No. 694522-87-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

GO289
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

GO289 (GO-289, GO 289) 是一种有效的选择性酪蛋白激酶 2 (CK2) 抑制剂，体外激酶测定中的 IC50 为 7 nM。
产品描述

GO289 (GO-289, GO 289) is a potent and selective inhibitor of casein kinase 2 (CK2) with IC50 of 7 nM in in vitro kinase assays, shows minor effects on CKIδ and CKIα activity in vitro; GO289 showed only a moderate or minor effect on the activity of 59 kinases from a variety of classes, the second most affected kinase was PIM2 with an IC50 of 13 nM; caused dose-dependent lengthening of circadian period not only in Bmal1-dLuc reporter cells but also in Per2-dLuc reporter cells with a phase opposite to that of Bmal1-dLuc, inhibits phosphorylation of clock protein PER2 S693 in cells; strongly inhibits Caki-2, A498, and 769-P cancer cells, significantly reduces growth of mouse MLL-AF9 leukemia cells without effect on hematopoietic progenitor cells; shows effectivity on circadian period and reporter signal intensity in spleen explants of MLL-AF9 mice.
体外实验

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体内实验

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同义词

GO-289 | GO 289
通路

Metabolic Enzyme/Protease
靶点

Casein Kinase
受体

Casein Kinase
研究领域

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适应症

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CAS Number

694522-87-7
分子量

419.297
分子式

C17H15BrN4O2S
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO : 16.67 mg/mL (39.76 mM)
SMILES

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化学全称

5-bromo-2-methoxy-4-(((3-(methylthio)-5-phenyl-4H-1,2,4-triazol-4-yl)imino)methyl)phenol

1. Tsuyoshi Oshima, et al. Science Advances 23 Jan 2019: Vol. 5, no. 1, eaau9060. DOI: 10.1126/sciadv.aau9060.

计算器

产品手册

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