IWP-2

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

IWP-2 是 Wnt 加工和分泌的抑制剂，在无细胞测定中 IC50 为 27 nM，选择性阻断 Porcn 介导的 Wnt 棕榈酰化，一般不影响 Wnt/β-连环蛋白，并且对 Wnt 刺激没有作用细胞反应。

IWP-2 is an inhibitor of Wnt processing and secretion with IC50 of 27 nM in a cell-free assay, selective blockage of Porcn-mediated Wnt palmitoylation, does not affect Wnt/β-catenin in general and displays no effect against Wnt-stimulated cellular responses.

IWP-2 (GMP) (2?μM, in the first 4?days of Stage IV induction medium) reprograms human somatic cells to pluripotent stem cells.IWP-2 (GMP) (5?μM, day 3 to 5) induces cardiac differentiation of hiPSCs.IWP-2 (GMP) (5 μM, day 1 to 3) increasing the expression of cardiac progenitors and cardiac genes (MYL2, TNNI3, and TNNT2) in hiPSCs.IWP-2 (GMP) (5 μM, day 5-7) together with PIP-S2 induces cardiac mesoderm differentiates into functional cardiomyocytes.IWP-2 (GMP) (5 μM, treated at day 3) induces cardiomyocyte differentiation when applied following a pretreatment with Laduviglusib (GMP) (HY-10182G). RT-PCR Cell Line:hiPSCs Concentration:5 μM Incubation Time:day 1 to 3 Result:Reduced the expression of anti-cardiac mesoderm genes, and increased the expression of cardiac progenitors and cardiac genes (MYL2, TNNI3, and TNNT2).

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Inhibitor of Wnt Production-2

Wnt/Notch/Hedgehog

Wnt/beta/catenin

Wnt

Cancer

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686770-61-6

466.6

C22H18N4O2S3

>98% (HPLC)

DMF: 22 mg/mL warming (47.14 mM); DMSO: 4 mg/mL warming (8.57 mM)

O=C(NC1=NC2=CC=C(C)C=C2S1)CSC3=NC(CCS4)=C4C(N3C5=CC=CC=C5)=O

N -(6-Methyl-2-benzothiazolyl)-2-[(3?,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2- d ]pyrim?idin-2-yl)thio]-acetamide

(-20℃)

With Ice Pack

≥ 2 years