AICAR phosphate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

AICAR 磷酸盐（Acadesine，AICA Riboside，NSC 105823）是肝细胞和脂肪细胞中的选择性 AMPK 激活剂。

AICAR phosphate (Acadesine, AICA Riboside, NSC 105823) is a selective AMPK activator in both hepatocytes and adipocytes; inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes at 0.5 mM, inhibits insulin-stimulated glucose and reduces GLUT4 translocation in 3T3-L1 adipocytes; down-regulates the insulin receptor expression in HepG2 cells.

HepG2 cells are treated with various concentrations of AICAR (0.1-1.0 mM) for 12, 24, and 48 h, respectively. The expression level of IR-β significantly decreases with 0.25, 0.5, and 1.0 mM of AICAR at 48 h to 50%, 53%, and 46% of the control, respectively.

Fourteen-week-old male, lean (L; 31.3 g body wt) wild-type andob/ob (O; 59.6 g body wt) mice are injected with the AMP-activated kinase (AMPK) activator AICAR (A) at 0.5 mg*g body wt-1*day-1 or saline control (C) for 14 days. At 24 h after the last injection (including a 12-h fast), all mice are killed, and the plantar flexor complex muscle (gastrocnemius, soleus, and plantaris) is excised for analysis. Muscle mass is lower in OC (159±12 mg) than LC, LA, and OA (176±10, 178±9, and 166±16 mg, respectively) mice, independent of a body weight change. The kidney weight is significantly higher in the untreated group when compared with both the exercise and AICAR (0.5 mg/g body wt) groups. The heart weight is higher in the exercise group than in the other groups, whereas the liver weight is significantly higher in the AICAR-treated group when compared with the exercise and untreated groups.

Acadesine phosphate | AICA Riboside phosphate

Membrane Transporter/Ion Channel

AMPK

AMPK

Metabolic Disease

——

681006-28-0

356.23

C9H17N4O9P

>98% (HPLC)

10 mM in H2O

C1=NC(=C(N1C2C(C(C(O2)CO)O)O)N)C(=O)N.OP(=O)(O)O

Imidazole-4-carboxamide, 5-amino-1-ribosyl-, phosphate

(-20℃)

With Ice Pack

≥ 2 years