Choline chloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

氯化胆碱是一种有机化合物和季铵盐、酰基受体和胆碱乙酰转移酶底物。

Choline chloride is an organic compound and a quaternary ammonium salt, an acyl group acceptor and choline acetyltransferase substrate, also is an important additive in feed especially for chickens where it accelerates growth.

Cell Viability Assay Cell Line:Rat pheochromocytoma cells PC12 Concentration:0 or 70 μM Incubation Time:4 days Result:Showed the cell viability of 94% at 70 μM while cell viability of 83% at 0 μM.Reduced the number of cells with DNA breaks (characteristic of apoptosis) by 8.5% at 70 μM compared to the no treatment group.

Animal Model:Postoperative pain model of female C57/Bl6 miceDosage:0.2 and 100 mg/kg/h Administration:Subcutaneous injection, 24 or 48 hours Result:Reduced heat hypersensitivity after surgery with maximal efficacy after 48 h treatment and the ED50 value of choline dose was 1.7 mg/kg/h.Reduced hypersensitivity to punctate mechanical stimuli 48 hours after infusion in a dose-dependent manner and with the ED50 value of 4.7 mg/kg/h but not 24 hours.

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Endocrinology/Hormones

AChR

mAChR

Other Indications

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67-48-1

139.63

C5H14ClNO

>98% (HPLC)

Ethanol: 28 mg/mL (200.54 mM); Water: 28 mg/mL (200.54 mM); DMSO: 28 mg/mL (200.54 mM)

[Cl-].C[N+](C)(C)CCO

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(-20℃)

With Ice Pack

≥ 2 years