Tolbutamide

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Tolbutamide 是一种钾通道抑制剂，用于治疗 II 型糖尿病。

Tolbutamide is an inhibitor of potassium channel, used for type II diabetes.

Western Blot Analysis Cell Line:Glioma cell Concentration:400 μM Incubation Time:24h Result:Increasing the level of Cx43.

Animal Model:Non-obese-diabetic mouse Dosage:125 mg/kg Administration:Supplemented in daily diet for 27 weeks Result:Showed 10 of 23 animals developed diabetes compared with 18 of 24 in the control groups.Animal Model:Pregnant mice Dosage:100 mg/kg, 400 mg/kg Administration:Intraperitoneal injection (i.p.) Result:Showed a significant reduction (50 %) in the frequency of living fetuses for the group of 400 mg/kg on day 13.

D 860 | NSC 23813 | NSC 87833 | U-2043

Cell Cycle/DNA Damage

Potassium Channel

Potassium Channel

Metabolic Disease

——

64-77-7

270.35

C12H18N2O3S

>98% (HPLC)

Ethanol: 54 mg/mL warmed (199.74 mM); DMSO: 54 mg/mL (199.74 mM)

O=C(NS(=O)(C1=CC=C(C)C=C1)=O)NCCCC

1-butyl-3-(4-methylphenyl)sulfonylurea

(-20℃)

With Ice Pack

≥ 2 years