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首页- Products - GPCR/G Protein - 5-HT Receptor - Mosapride citrate dihydrate

Mosapride citrate dihydrate

CAS No. 636582-62-2

Mosapride citrate dihydrate ( AS-4370 citrate | TAK-370 )

产品货号. M15413 CAS No. 636582-62-2

Mosapride citrate (AS-4370 citrate) 是一种促胃动力剂，可作为选择性 5HT4 激动剂。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ￥808 有现货
500MG 获取报价 有现货
1G 获取报价 有现货
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生物学信息

  • 产品名称
    Mosapride citrate dihydrate
  • 注意事项
    本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
  • 产品简述
    Mosapride citrate (AS-4370 citrate) 是一种促胃动力剂，可作为选择性 5HT4 激动剂。
  • 产品描述
    Mosapride citrate (AS-4370 citrate) is a gastroprokinetic agent that acts as a selective 5HT4 agonist; accelerates gastric emptying throughout the whole of the gastrointestinal tract invivo, and is used for the treatment of gastritis, gastro-oesophageal reflux disease, functional dyspepsia and irritable bowel syndrome.Other Indication Phase 2 Clinical.
  • 体外实验
    Mosapride (0.3-30 μM) exhibits an inhibitory activity against Kv4.3 with an IC50 of 15.2 μM in a concentration-dependent manner. Mosapride also inhibits the open state of Kv4.3 currents during depolarization and accelerates the closed-state inactivation at subthreshold potentials.
  • 体内实验
    Mosapride (Intravenous injection;0.3-3 mg/kg) dose-dependently increases the antral motor activity in conscious dogs which indicates that mosapride selectively stimulates upper gastrointestinal motility. Animal Model:Beagle dogsDosage:0.3-3 mg/kgAdministration:Intravenous injection; 0.3-3 mg/kg Result:Increased the antral motor activity dose-dependently in conscious dogs.
  • 同义词
    AS-4370 citrate | TAK-370
  • 通路
    GPCR/G Protein
  • 靶点
    5-HT Receptor
  • 受体
    5-HT Receptor
  • 研究领域
    Other Indications
  • 适应症
    Other Disease

化学信息

  • CAS Number
    636582-62-2
  • 分子量
    614.02
  • 分子式
    C27H33ClFN3O10
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    CCOC1=CC(=C(C=C1C(=O)NCC2CN(CCO2)CC3=CC=C(C=C3)F)Cl)N.C(C(=O)O)C(CC(=O)O)(C(=O)O)O.O.O
  • 化学全称
    4-Amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methyl]benzamide citrate

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Kato S, et al. J Med Chem. 1991 Feb;34(2):616-24. 2. Yoshida N, et al. J Pharmacol Exp Ther. 1991 May;257(2):781-7. 3. Sakashita M, et al. Arzneimittelforschung. 1993 Aug;43(8):859-63.
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