LY-404039

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

mGlu2 和 mGlu3 受体的有效选择性激动剂，Ki 分别为 149 nM 和 92 nM。

A potent, slective agonist of mGlu2 and mGlu3 receptors with Ki of 149 nM and 92 nM, respectively; displays >100-fold selectivity over other ionotropic glutamate receptors, glutamate transporters; suppresses electrically evoked excitatory activity in the striatum, and serotonin-induced l-glutamate release in the prefrontal cortex; reduces alcohol-seeking but not alcohol self-administration in alcohol-preferring (P) rats; oral bioavailable. Schizophrenia Phase 1 Clinical.

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LY 2140023 | LY404039

GPCR/G Protein

mGluR

RatneuronsexpressingnativemGlu2/3|RecombinanthumanmGlu2|RecombinanthumanmGlu3

Neurological Disease

Schizophrenia

635318-11-5

235.2145

C7H9NO6S

>98% (HPLC)

DMSO:1 mg/mL;H2O:< 1 mg/mL

O=S1(C[C@](C(O)=O)(N)[C@@H]2[C@@H](C(O)=O)[C@@H]21)=O

2-Thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid, 4-amino-, 2,2-dioxide, (1R,4S,5S,6S)-

(-20℃)

With Ice Pack

≥ 2 years