Beta-Hydroxyisovaleric acid

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

3-Hydroxyisovaleric acid 是尿液中排泄的正常内源性代谢产物 (endogenous metabolite)。3-Hydroxyisovaleric acid 的尿排泄是生物素缺乏的早期和敏感指标。

Used as pharmaceutical intermediates.

The reduced activity of methylcrotonyl-CoA carboxylase (MCC) leads to an elevated excretion of 3-methylcrotonic acid, the product of its hydration (3-hydroxyisovaleric acid: 3-HIA), and 3-methylcrotonylglycine, formed by conjugation with glycine.

In male mice (ICR/Jcl) at 8 weeks of age fed the biotin-deficient diet for 6 weeks, the concentration of urinary 3-Hydroxyisovaleric acid is 114.2 mM creatinine, which is higher than the concentration of 35.2 mM creatinine in mice fed the biotin-deficient diet for 4 weeks.

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Others

Other Targets

Others

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625-08-1

118.13

C5H10O3

>98% (HPLC)

Limited solubility

CC(C)(O)CC(O)=O

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(-20℃)

With Ice Pack

≥ 2 years