Dimethyl fumarate ( DMF | BG-12 )

产品货号. M15362 CAS No. 624-49-7

富马酸二甲酯 (DMF;BG-12) 在多种细胞类型中发挥抗炎和促代谢作用。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
500MG	￥300	有现货
1G	获取报价	有现货
1 mL x 10 mM in DMSO	￥437	有现货

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生物学信息

产品名称

Dimethyl fumarate
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

富马酸二甲酯 (DMF;BG-12) 在多种细胞类型中发挥抗炎和促代谢作用。
产品描述

Dimethyl fumarate (DMF;BG-12) exerts anti-inflammatory and pro-metabolic effects in a variety of cell types; an effective novel treatment for multiple sclerosis; activates the Nrf2 pathway and has been identified as a nicotinic acid receptor agonist in vitro.Multiple Sclerosis Approved.
体外实验

Cell Viability Assay Cell Line:SGC-7901, HT29, HCT116 and CT26 cells Concentration:20 μM, 50 μM, 100 μM, 200?μM Incubation Time:24 hours Result:Reduced cell viability in SGC-7901, HT29, HCT116 and CT26 cancer cells.Western Blot Analysis Cell Line:CT26 cancer cells Concentration:100 μM Incubation Time:3 hours, 6 hours, 12 hours, 24 hours Result:Significantly activated JNK, p38 and ERK in CT26 cells after treatment from 3 to 24?h.
体内实验

Animal Model:Male C57BL/6 mice (8-week-old)Dosage:50 mg/kg Administration:Oral gavage; daily; for 7 days Result:Was shown to upregulate mRNA and protein levels of Nrf2 and Nrf2-regulated cytoprotective genes.
同义词

DMF | BG-12
通路

Nuclear Receptor/Transcription Factor
靶点

Keap1-Nrf2
受体

KEAP1-Nrf2
研究领域

Inflammation/Immunology
适应症

Multiple Sclerosis

化学信息

CAS Number

624-49-7
分子量

144.1253
分子式

C6H8O4
纯度

>98% (HPLC)
溶解度

DMSO: 9.6 mg/mL
SMILES

O=C(OC)/C=C/C(OC)=O
化学全称

2-Butenedioic acid (2E)-, 1,4-dimethyl ester

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1. Peng H, et al. J Biol Chem. 2012 Aug 10;287(33):28017-26. 2. Ashrafian H, et al. Cell Metab. 2012 Mar 7;15(3):361-71. 3. Scannevin RH, et al. J Pharmacol Exp Ther. 2012 Apr;341(1):274-84.

计算器

浓度计算器

摩尔计算器

分子量计算器

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