Amrinone

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种正性肌力强心剂（强心剂），具有血管扩张特性、磷酸二酯酶 3 抑制活性以及刺激钙离子流入心肌细胞的能力。

A positive inotropic cardiotonic (cardiotonic agents) with vasodilator properties, phosphodiesterase 3 inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell.(In Vitro):Amrinone (Inamrinone) produced a dose-dependent inhibition of ADP-induced rat platelet aggregation in vitro as well as ex vivo in rats. The proliferation of human aortic smooth muscle cells in culture stimulated with FBS or PDGF was also inhibited by amrinone.(In Vivo):Amrinone (Inamrinone) is administered subcutaneously to rats at a dose of 10 mg/kg/day for 14 days, significant reduction of neointimal thickness was noted.

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WIN 40,680

Angiogenesis

PDE

PDE| TNF-α

Cardiovascular Disease

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60719-84-8

187.2

C10H9N3O

>98% (HPLC)

DMSO: 10 mM

C1=CN=CC=C1C2=CNC(=O)C(=C2)N

3-amino-5-pyridin-4-yl-1H-pyridin-2-one

(-20℃)

With Ice Pack

≥ 2 years