Fexinidazole

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Fexinidazole (HOE 239) 是一种具有口服活性的，有效的硝基咪唑抗锥虫活性分子。Fexinidazole 显示出对布鲁氏杆菌 (T. brucei) 亚种和菌株的杀锥虫活性，IC50 值为 0.7-3.3 μM (0.2-0.9 μg/ml)。Fexinidazole 具有用于因感染布鲁氏菌引起的人类昏睡病 (HAT) 的潜力。

Fexinidazole is an antiparasitic agent. It has activity against Trypanosoma cruzi, Tritrichomonas foetus, Trichomonas vaginalis, Entamoeba histolytica, Trypanosoma brucei, and Leishmania donovani. The biologically relevant active metabolites in vivo are the sulfoxide and sulfone.(In Vitro):Fexinidazole (HOE 239) has two principal metabolites, sulfoxide and sulfone. They have shown trypanocidal activity in vitro with IC50s of 0.7-3.3 μM (0.2-0.9 μg/ml) range against all parasite strains tested.(In Vivo):Fexinidazole (HOE 239; 20-50 mg/kg/day of IP or 25-100 mg/kg/day of PO; four consecutive days) has antitrypanosomal activities.

Fexinidazole (HOE 239) has two principal metabolites, sulfoxide and sulfone. They have shown trypanocidal activity in vitro with IC50s of 0.7-3.3 μM (0.2-0.9 μg/ml) range against all parasite strains tested.

Fexinidazole (HOE 239; 20-50 mg/kg/day of IP or 25-100 mg/kg/day of PO; four consecutive days) has antitrypanosomal activities. Animal Model:Adult female NMRI mice weighing between 20 and 25 g T. b. rhodesienseDosage:20, 50 mg/kg (IP) or 25, 50, 100 mg/kg (PO) Administration:IP or PO; daily; four consecutive days Result:Had antitrypanosomal activities, with 100 mg/kg/day p.o. being 100% curative.

Fexinidazole | Hoe-239 | Hoe 239 | Hoe239

Others

Other Targets

antiparasitic

Infection

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59729-37-2

279.31

C12H13N3O3S

>98% (HPLC)

DMSO: 10 mM

O=[N+](C1=CN=C(COC2=CC=C(SC)C=C2)N1C)[O-]

1-Methyl-2-((p-(methylthio)phenoxy)methyl)-5-nitroimidazole

(-20℃)

With Ice Pack

≥ 2 years