Orciprenaline sulfate ( dl-Metaproterenol | dl-Orciprenaline )

产品货号. M15165 CAS No. 5874-97-5

一种 β2 肾上腺素能激动剂，用于治疗哮喘和支气管痉挛。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥130	有现货
10MG	￥177	有现货
25MG	￥269	有现货
50MG	￥384	有现货
500MG	获取报价	有现货
1G	获取报价	有现货
1 mL x 10 mM in DMSO	￥148	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

Orciprenaline sulfate
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

一种 β2 肾上腺素能激动剂，用于治疗哮喘和支气管痉挛。
产品描述

A beta-2 adrenergic agonist used in the treatment of asthma and bronchial spasm.(In Vitro):Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment enhances β-arrestin2 and its interaction with IκBα in high glucose-induced THP-1 cells and bone marrow macrophages.Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment leads to downregulation of NF-κB in high glucose-induced THP-1 cells and bone marrow macrophages.(In Vivo):Treatment of Zucker diabetic fatty rats with Metaproterenol for 12 weeks attenuates monocyte activation as well as pro-inflammatory and pro-fibrotic responses in the kidneys and heart. Thus, Metaproterenol might has protective effects against diabetic renal and cardiovascular complications.
体外实验

Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment enhances β-arrestin2 and its interaction with IκBα in high glucose-induced THP-1 cells and bone marrow macrophages. Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment leads to down regulation of NF-κB in high glucose-induced THP-1 cells and bone marrow macrophages. Western Blot Analysis Cell Line:THP-1 cells and bone marrow macrophages Concentration:10 μM Incubation Time:74 hoursResult:Enhanced β-arrestin2 and its interaction with IκBα.RT-PCR Cell Line:THP-1 cells and bone marrow macrophages Concentration:10 μM Incubation Time:74 hours Result:Led to downregulation of NF-κB.
体内实验

Treatment of Zucker diabetic fatty rats with Metaproterenol for 12 weeks attenuates monocyte activation as well as pro-inflammatory and pro-fibrotic responses in the kidneys and heart. Thus, Metaproterenol might has protective effects against diabetic renal and cardiovascular complications.
同义词

dl-Metaproterenol | dl-Orciprenaline
通路

Endocrinology/Hormones
靶点

Adrenergic Receptor
受体

β-adrenergic receptor
研究领域

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适应症

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