Metyrapone

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Metyrapone 是细胞色素 P450 介导的 ω/ω-1 羟化酶活性和 CYP11B1 的抑制剂。

Metyrapone is an inhibitor of cytochrome P450-mediated ω/ω-1 hydroxylase activity and CYP11B1.(In Vitro):Metyrapone (100?μM; 2 h) hyperactivates autophagy in HepG2, and delays the activation of apoptosis at severe endoplasmic reticulum (ER) stress.(In Vivo):Metyrapone (25 or 50 mg/kg; SC, single dosage) decreases the stress-induced increase in plasma corticosterone levels, significantly impairs acquisition performance at high dosage, and increases open arm activity at low dosage.

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Animal Model:Male Sprague-Dawley rats (n=179; 270-300g)Dosage:25 or 50 mg/kg (in a volume of 2.0 mL/kg) Administration:SC, single dosage Result:Dose-dependently decreased the stress-induced increase in plasma corticosterone levels in the water maze test; the high level dose significantly impaired acquisition performance in the water maze and decreased fear-induced immobility; the lower dose increased open arm activity.

NSC 25265 | SU 4885

Others

Other Targets

Camphor 5-monooxygenase

Metabolic Disease

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54-36-4

226.27

C14H14N2O

>98% (HPLC)

sparingly soluble in Water

CC(C1=CC=CN=C1)(C)C(C2=CC=CN=C2)=O

2-methyl-1,2-dipyridin-3-ylpropan-1-one

(-20℃)

With Ice Pack

≥ 2 years