Metyrapone ( NSC 25265 | SU 4885 )

产品货号. M14949 CAS No. 54-36-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Metyrapone
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Metyrapone 是细胞色素 P450 介导的 ω/ω-1 羟化酶活性和 CYP11B1 的抑制剂。
产品描述

Metyrapone is an inhibitor of cytochrome P450-mediated ω/ω-1 hydroxylase activity and CYP11B1.(In Vitro):Metyrapone (100?μM; 2 h) hyperactivates autophagy in HepG2, and delays the activation of apoptosis at severe endoplasmic reticulum (ER) stress.(In Vivo):Metyrapone (25 or 50 mg/kg; SC, single dosage) decreases the stress-induced increase in plasma corticosterone levels, significantly impairs acquisition performance at high dosage, and increases open arm activity at low dosage.
体外实验

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体内实验

Animal Model:Male Sprague-Dawley rats (n=179; 270-300g)Dosage:25 or 50 mg/kg (in a volume of 2.0 mL/kg) Administration:SC, single dosage Result:Dose-dependently decreased the stress-induced increase in plasma corticosterone levels in the water maze test; the high level dose significantly impaired acquisition performance in the water maze and decreased fear-induced immobility; the lower dose increased open arm activity.
同义词

NSC 25265 | SU 4885
通路

Others
靶点

Other Targets
受体

Camphor 5-monooxygenase
研究领域

Metabolic Disease
适应症

——

1.Shiro Y, et al. Biochemistry. 1995 Jul 18;34(28):9052-8.

计算器

产品手册

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