Myricetin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

杨梅素是由母体化合物花旗松素通过 (+)-二氢杨梅素中间体产生的，可以进一步加工形成落叶松素和注射剂，这两种物质都属于黄酮类化合物的黄酮醇类。

Myricetin is produced from the parent compound taxifolin through the (+)-dihydromyricetin intermediate and can be further processed to form laricitrin and then syringetin, both members of the flavonol class of flavonoids. Dihydromyricetin is frequently sold as a supplement and has controversial function as a partial GABAA receptor potentiator and treatment in Alcohol Use Disorder (AUD). (In Vitro):Myricetin exhibits the scavenging activity towards a number of radicals and ions. It displays poor activity (IC50 value=1.4 mg/mL) in a superoxide dismutase (SOD)-like activity assay. It prevents cancer cell death via apoptosis via regulation of PI3K/Akt and MAPK signalling pathways. Myricetin exhibits antiphotoaging effects by quenching causative free radicals in the skin. Myricetin is able to suppress UVB-induced COX-2 expression in mouse skin epidermal JB6 P+ cells. It inhibits UVB-induced initiation of activator protein-1 and NF-κβ, as well as Fyn kinase activity. Myricetin inhibits viability of SKOV3 ovarian cancer cells in a dose-dependent manner. It induces DNA DSBs and ER stress, which leads to apoptosis in SKOV3 cells. Myricetin inhibits human Hsp70 by more than 80% with IC50 values of 83, 11 and 12 μM, respectively.(In Vivo):Treatment of orthotopic pancreatic tumors with myricetin results in tumor regression and decreases metastatic spread. Exposure to 150 μM myricetin causes 14%, 26%, 5% and 49% inhibition of rabbit platelet aggregation, induced by ADP, arachidonic acid, collagen and PAF, respectively.

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Cannabiscetin | NSC 407290

PI3K/Akt/mTOR signaling

PI3K

PI3Kγ

Cancer

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529-44-2

318.24

C15H10O8

>98% (HPLC)

Ethanol: 20 mg/mL warmed (62.84 mM); DMSO: 63 mg/mL (197.96 mM)

O=C1C(O)=C(C2=CC(O)=C(O)C(O)=C2)OC3=C1C(O)=CC(O)=C3

3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one

(-20℃)

With Ice Pack

≥ 2 years