SW-044248 ( SW 044248 | SW044248 )

产品货号. M14846 CAS No. 522650-83-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

产品询价大包装询价加入购物车

产品名称

SW-044248
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

SW-044248是一种新型选择性拓扑异构酶I抑制剂；对 Top I 的抑制作用与喜树碱不同。
产品描述

SW-044248 is a novel selective inhibitor of Topoisomerase I; inhibits Top I differently from camptothecin; selectively toxic for some NSCLC cell lines.Lung Cancer Preclinical.
体外实验

SW044248 is a non-canonical Top1 inhibitor, and is selectively toxic for certain NSCLC cell lines. SW044248 shows no effect on Top2. SW044248 (2, 5, 10 μM) rapidly inhibits transcription, translation and DNA synthesis in sensitive cells (HCC4017 and H292 cells) but not insensitive cells (HBEC30KT cells and HCC44 cells). SW044248 (10 μM) rapidly activates the integrated stress response through kinases GCN2 and PKR. The inhibition of Top1 in HCC4017 cells is helpful to the toxicity of SW044248. SW044248 (5, 10 μM) shows no effect on HBEC30KT and HCC44 cell lines due to the up-regulation of p21CDKN1A. SW044248 is selectively toxic in 18/74 NSCLC lines.
体内实验

——
同义词

SW 044248 | SW044248
通路

Cell Cycle/DNA Damage
靶点

Topoisomerase
受体

TopoI
研究领域

Cancer
适应症

Lung Cancer

CAS Number

522650-83-5
分子量

421.5153
分子式

C22H23N5O2S
纯度

>98% (HPLC)
溶解度

DMSO: ≥ 30 mg/mL
SMILES

CCN1C2=CC=CC=C2C3=C1N=C(N=N3)SC(C(NC4=CC=CC=C4OC)=O)CC
化学全称

Butanamide, 2-[(5-ethyl-5H-1,2,4-triazino[5,6-b]indol-3-yl)thio]-N-(2-methoxyphenyl)-

1. Zubovych IO, et al. Mol Cancer Ther. 2016 Jan;15(1):23-36. 2. Kim HS, et al. Cell. 2013 Oct 24;155(3):552-66.

计算器

产品手册

关联产品

Proscillaridin A

Proscillaridin A 是一种天然产物。它是拓扑异构酶 I/II 活性的强毒物，IC50 值分别为 30 nM 和 100 nM。
Eleutherin

Eleutherin is a natural product from Eleutherine americana
7-Epitaxol

7-Epitaxol 是细胞中发现的紫杉醇的主要衍生物，它的存在不会在很大程度上改变紫杉醇的整体生物活性。