Aloe-emodin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

芦荟大黄素是一种干扰素诱导剂，对于 JEV 的 IC50 约为 1 μg/mL，对于 EV71 的 IC50 约为 0.33 μg/mL。

Aloe-emodin is an interferon-inducing agent with IC50 of about 1 μg/mL for JEV and of about 0.33 μg/mL for EV71.

Cell Viability Assay Cell Line:PC3 cells Concentration:0 μM, 2.5 μM, 5 μM, 10 μM or 15 μM Incubation Time:24 h, 48 h, 72 h or 96 h Result:Suppressed proliferation and anchorage-independent growth of PC3 cells.Western Blot AnalysisCell Line:PC3 cells Concentration:0 μM, 2.5 μM, 5 μM, 10 μM or 15 μM Incubation Time:24 h Result:Inhibited the activation of the downstream substrates of mTORC2, Akt and PKCα.

Animal Model:Athymic nude mice (BALB/c nude mouse, 6 weeks old) Dosage:10 mg/kg, 50 mg/kg (20% PEG400 in autoclaved PBS) Administration:Intraperitoneal injection, five times per week; for 28 days Result:Exhibited tumor suppression effects in vivo in an athymic nude mouse model.

3-Hydroxymethylchrysazine | NSC 38628 | Rhabarberone

Microbiology/Virology

HSV

HSV-1| HSV-2

Cancer

——

481-72-1

270.24

C15H10O5

>98% (HPLC)

DMSO: 3 mg/mL (11.1 mM)

O=C(C1=C2C(O)=CC=C1)C3=CC(CO)=CC(O)=C3C2=O

1,8-dihydroxy-3-(hydroxymethyl)anthracene-9,10-dione

(-20℃)

With Ice Pack

≥ 2 years