Azathioprine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

硫唑嘌呤是一种免疫抑制化合物，抑制嘌呤合成和GTP结合蛋白Rac1激活，用于治疗器官移植和自身免疫性疾病。

Azathioprine is an immunosuppressive drug, inhibiting purine synthesis and GTP-binding protein Rac1 activation, used in the treatment of organ transplantation and autoimmune diseases.(In Vitro):Azathioprine (0-50 μM, 48 hours) can induce severe intracellular GSH depletion with relevant concentrations in both primary rat and human hepatocytes.(In Vivo):Azathioprine (oral gavage, 25-400 mg/kg, everyday, 10days) can affect bone marrow cells, red blood cells, and peripheral blood cytokines and other related parameters in a dose-dependent manner, and can induce apoptosis in female CD-1 mice and ICR mice.

Azathioprine (0-50 μM, 48 hours) can induce severe intracellular GSH depletion with relevant concentrations in both primary rat and human hepatocytes. Cell Viability Assay Cell Line:Rat hepatocytes, Human hepatocytes Concentration:0-50 μM Incubation Time:24-48 hours Result:Showed the decrease in cell viability and intracellular GSH levels in rat hepatocytes as low concentration of 0.5 μM but no significant decrease in cell viability at concentrations below 50 μM as well as GSH depletion was obviously noted at a concentration as low as 1 μM in human hepatocytes.

Azathioprine (oral gavage, 25-400 mg/kg, everyday, 10days) can affect bone marrow cells, red blood cells, and peripheral blood cytokines and other related parameters in a dose-dependent manner, and can induce apoptosis in female CD-1 mice and ICR mice. Animal Model:Outbred female CD-1 mice, Female ICR mice Dosage:25-400 mg/kg Administration:Oral gavage; everyday; 10 days Result:Induced a decrease in erythrocyte-related parameters as well as leukocyte-related parameters in a dose-dependent manner.Induced 52.4%, 35.4%, 17.9%, 16.1% and 15.2% reduction in bone marrow cells at concentrations of 40, 60, 80, 100 and 120 mg/kg, respectively while fms-like tyrosine kinase-3(FLT-3) ligand (FL)-related cytokines were increased.

Azamune | Azoran | BW 57-322 | Imuran | NSC 39084

Cell Cycle/DNA Damage

GPR

HGPRT| Rac1

Inflammation/Immunology

——

446-86-6

277.26

C9H7N7O2S

>98% (HPLC)

DMSO: 54 mg/mL (194.76 mM)

O=[N+](C1=C(SC2=C3NC=NC3=NC=N2)N(C)C=N1)[O-]

6-((1-methyl-4-nitro-1H-imidazol-5-yl)thio)-7H-purine

(-20℃)

With Ice Pack

≥ 2 years