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LDN 91946
CAS No. 439946-22-2
LDN 91946 ( LDN91946 )
产品货号. M14496 CAS No. 439946-22-2
LDN 91946 是一种选择性、非竞争性泛素 C 末端水解酶-L1 (UCH-L1) 抑制剂，Ki 为 2.8 uM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥103 | 有现货 |
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| 5MG | ￥145 | 有现货 |
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| 10MG | ￥236 | 有现货 |
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| 25MG | ￥369 | 有现货 |
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| 50MG | ￥556 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
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| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥163 | 有现货 |
|
生物学信息
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产品名称LDN 91946
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述LDN 91946 是一种选择性、非竞争性泛素 C 末端水解酶-L1 (UCH-L1) 抑制剂，Ki 为 2.8 uM。
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产品描述LDN 91946 is a selective, uncompetitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor with Ki of 2.8 uM, exhibits no activity against other cysteine hydrolase (UCH-L3, TGase 2, papain and caspase-3).
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体外实验LDN-91946 is inactive against UCH-L3 at 20 μM. LDN-91946 demonstrates no activity against TGase 2, Papain, and Caspase-3 at 40 μM. There is no cytotoxicity when serum-starved Neuro 2A (N2A) cells are treated with LDN-91946 at concentrations as high as 0.1 mM.
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体内实验——
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同义词LDN91946
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通路Proteasome/Ubiquitin
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靶点DUB
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受体DUB
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研究领域——
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适应症——
化学信息
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CAS Number439946-22-2
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分子量316.32
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分子式C17H12N6O
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 83.33 mg/mL (265.11 mM)
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SMILESC1(NC2=CC=CN=C2)=NC=C(C3=NC=NC=C3)C(C4=CC=CO4)=N1
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化学全称3-amino-2-(benzoyl)-6-oxo-7H-thieno[3,2-e]pyridine-5-carboxylic acid
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Mermerian AH, et al. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3729-32.
2. Coulombe J, et al. Front Aging Neurosci. 2014 Jun 19;6:129.
