Nadolol ( Nadolol, Corgard, Solgol, SQ-11725, Anabet )

产品货号. M14436 CAS No. 42200-33-9

一种半衰期长的非选择性β-肾上腺素能拮抗剂，用于心血管疾病治疗心律失常、心绞痛和高血压。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥1036	有现货
500MG	获取报价	有现货
1G	获取报价	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

Nadolol
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

一种半衰期长的非选择性β-肾上腺素能拮抗剂，用于心血管疾病治疗心律失常、心绞痛和高血压。
产品描述

A non-selective beta-adrenergic antagonist with a long half-life, used in cardiovascular disease to treat arrhythmias, angina pectoris, and hypertension. Nadolol is also used for MIGRAINE DISORDERS and for tremor.(In Vitro):In human embryonic kidney 293 cells, (-)-Epigallocatechin gallate (EGCG) competitively inhibits OATP1A2-mediated uptake of Nadolol with a Ki value of 19.4 μM. With respect to Nadolol, the Km for OATP1A2 is 84 μM.(In Vivo):In male OF1 mice bearing B16F10 tumor cells, blocking the neuroendocrine response through the administration of Nadolol (20 mg/kg) results in fewer and smaller pulmonary metastatic foci in subjects exposed to acute social stress.
体外实验

In human embryonic kidney 293 cells, (-)-Epigallocatechin gallate (EGCG) competitively inhibits OATP1A2-mediated uptake of Nadolol with a Ki value of 19.4 μM. With respect to Nadolol, the Km for OATP1A2 is 84 μM.
体内实验

In male OF1 mice bearing B16F10 tumor cells, blocking the neuroendocrine response through the administration of Nadolol (20 mg/kg) results in fewer and smaller pulmonary metastatic foci in subjects exposed to acute social stress.
同义词

Nadolol, Corgard, Solgol, SQ-11725, Anabet
通路

Endocrinology/Hormones
靶点

Adrenergic Receptor
受体

β-adrenergic receptor
研究领域

——
适应症

——

化学信息

CAS Number

42200-33-9
分子量

309.4
分子式

C17H27NO4
纯度

>98% (HPLC)
溶解度

soluble in Water
SMILES

O[C@@H]1CC2=C(C(OCC(O)CNC(C)(C)C)=CC=C2)C[C@@H]1O
化学全称

(2R,3S)-5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol