RI-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

RI-1 是一种 RAD51 抑制剂，IC50 范围为 5 至 30μM。

RI-1 is a RAD51 inhibitor with IC50 ranging from 5 to 30μM.

RI-1 (1-50 μM; 24 h) specifically inhibits homologous recombination (HR) in U2OS cells and stimulates single-strand annealing (SSA) in HEK293 cells.?RI-1 (5-20 μM; 30 min) inhibits HsRAD51 in a concentration-dependent manner.RI-1 (20 μM; 8 h) disrupts the formation of RAD51 foci after DNA damage in immortalized human fibroblasts.?RI-1 (15-25 μM; 24 h) sensitizes human cancer cells (HeLa, MCF-7 and U2OS) to cross-linking chemotherapy.

RI-1 (50 mg/kg; i.p. every 3 d for 30 d) significantly reduces triple negative breast cancer (TNBC) tumor growth in mice. Animal Model:Female BALB/c nude mice (6 weeks) bearing TNBC tumorDosage:50 mg/kg Administration:I.p. every 3 days for 30 days Result:Resulted in significant inhibition of tumor growth.

RI-1 | RI1 | RI 1

Cell Cycle/DNA Damage

DNA/RNA Synthesis

RAD51

Cancer

——

415713-60-9

361.61

C14H11Cl3N2O3

>98% (HPLC)

DMSO: 50 mg/mL (138.27 mM)

ClC1=C(N2CCOCC2)C(=O)N(C1=O)C1=CC(Cl)=C(Cl)C=C1

3-chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione

(-20℃)

With Ice Pack

≥ 2 years