CMPD-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种有效、选择性、非 ATP 竞争性 p38α 介导的 MK2a 磷酸化抑制剂，表观 Ki 为 330 nM。

A potent, selective, non-ATP-competitive inhibitor of p38α-mediated MK2a phosphorylation with apparent Ki of 330 nM; dose not prevents p38α-mediated phosphorylation of MBP and ATF-2; induces a significant G2/M arrest, also inhibits tubulin polymerization in glioblastoma cells.

CMPD1 does not inhibit p38 MAPK-mediated phosphorylation of other two substrates, MBP and ATF2.CMPD1 induced mitotic arrest and apoptosis in U87 cells.CMPD1 inhibits tubulin polymerisation in glioblastoma cells.

——

CMPD 1 | CMPD1

MAPK/ERK Signaling

p38 MAPK

p38 MAPK

——

——

41179-33-3

349.4

C22H20FNO2

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (286.20 mM)

O=C(NC1=CC=C(O)C=C1)CCCC2=CC=C(C3=CC=CC=C3F)C=C2

4-(2'-fluoro-[1,1'-biphenyl]-4-yl)-N-(4-hydroxyphenyl)butanamide

(-20℃)

With Ice Pack

≥ 2 years