Andarine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Andarine (S-4;GTx007) 是一种非类固醇选择性雄激素受体调节剂 (SARM)，Ki 为 4 nM。

Andarine (S-4;GTx007) is a non-steroidal selective androgen receptor modulator (SARM) with Ki of 4 nM, efficaciously stimulated AR-mediated reporter gene expression; demonstrates in vivo androgenic and anabolic activity, stimulates the anabolic organs more than the androgenic organs; improves muscle strength and body composition and prevents bone loss in orchidectomized rats.(In Vivo):GTx-007 (S-4) is only a partial agonist in the prostate and seminal vesicles, restoring them to 33.8 and 28.2% of intact animals, respectively.GTx-007 significantly increased uterine expression of Wnt4 and Wnt7a.

——

GTx-007 (S-4) is only a partial agonist in the prostate and seminal vesicles, restoring them to 33.8 and 28.2% of intact animals, respectively.GTx-007 significantly increased uterine expression of Wnt4 and Wnt7a. Animal Model:Female C57BL/6J mice.Dosage:0.5?mg/mouse.Administration:Seven daily subcutaneous injections.Result:Resulted in a highly heterogeneous pattern of AR expression in all compartments, with a significant increase of AR-positive cells in the luminal epithelium compared to VC.Had approximately ten glands per uterine cross-section within an endometrium, with a compact stroma, consistent with overall endogenous steroid depletion.

GTx-007 | S-4 | GTx007

Endocrinology/Hormones

Androgen Receptor (AR)

AndrogenReceptor

Cancer

——

401900-40-1

441.3579

C19H18F3N3O6

>98% (HPLC)

10 mM in DMSO

O=C(NC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1)[C@@](C)(O)COC2=CC=C(NC(C)=O)C=C2

Propanamide, 3-[4-(acetylamino)phenoxy]-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-, (2S)-

(-20℃)

With Ice Pack

≥ 2 years