Selective antagonist of formyl peptide receptor 2 (FPR2) signaling. Inhibits WKYMVm binding to FPR2 (IC50 = 0.23 μM) and inhibits intracellular calcium release induced by WKYMVm, MMK 1, amyloid β42, and F peptide. Also inhibits FPR2-mediated signaling in human neutrophils; blocks chemotactic migration and superoxide generation by amyloid β42 peptide.

4-PQBH 是一种有效的 Nur77 粘结剂 (KD=1.17 μM)。4-PQBH 通过 nur77 介导的内质网应激和自噬广泛诱导 caspase 不依赖的细胞质空泡化和凋亡。4-PQBH 可用于癌症研究。

ACBI3 是一种泛 KRAS 降解剂。 ACBI3 实现致癌 KRAS 的体内降解。