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A-317567
CAS No. 371217-32-2
A-317567 ( A317567 )
产品货号. M14278 CAS No. 371217-32-2
A-317567 (A317567) 是一种新型强效酸传感离子通道 (ASIC) 阻断剂，IC50 为 2-30 uM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥3021 | 有现货 |
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| 50MG | ￥17091 | 有现货 |
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| 100MG | ￥25515 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称A-317567
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A-317567 (A317567) 是一种新型强效酸传感离子通道 (ASIC) 阻断剂，IC50 为 2-30 uM。
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产品描述A-317567 (A317567) is a novel potent acid sensing ion channel (ASIC) blocker with IC50 of 2-30 uM; inhibits pH 4.5-evoked ASIC currents, also equipotently blocks the sustained phase of ASIC3-like current; is more potent than amiloride in vitro and in vivo pain models, with minimal brain penetration.Pain Discontinued.
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体外实验——
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体内实验Animal Model:Adult male Sprague-Dawley rats (230-350 g) injected with Complete Freund’s Adjuvant- (CFA-) induced thermal hyperalgesia.Dosage:1-100 μmol/kg Administration:i.p; once Result:Showed dose-dependent analgesic effects.
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同义词A317567
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通路Membrane Transporter/Ion Channel
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靶点Sodium Channel
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受体Sodium Channel
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研究领域Neurological Disease
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适应症Pain
化学信息
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CAS Number371217-32-2
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分子量397.566
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分子式C27H31N3
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESN=C(C1=CC=C2C=C(C3C(C4=CC5=C(C=C4)CCN(C)C5C(C)C)C3)C=CC2=C1)N
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化学全称6-{2-[2-methyl-1-(propan-2-yl)-1,2,3,4-tetrahydroisoquinolin-7-yl]cyclopropyl}naphthalene-2-carboximidamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Dubé GR, et al. Pain. 2005 Sep;117(1-2):88-96.
2. Hayes SG, et al. Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1720-5.
3. Dwyer JM, et al. Psychopharmacology (Berl). 2009 Mar;203(1):41-52.
4. Kuduk SD, et al. ACS Chem Neurosci. 2010 Jan 20;1(1):19-24.
