FCCP ( Trifluoromethoxy carbonylcyanide phenylhydrazone )

产品货号. M14275 CAS No. 370-86-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

FCCP
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

FCCP 是线粒体氧化磷酸化的有效解偶联剂，可通过跨细胞膜运输质子来破坏 ATP 合成。
产品描述

FCCP is a potent uncoupler of oxidative phosphorylation in mitochondria that disrupts ATP synthesis by transporting protons across cell membranes.(In Vitro):FCCP (5 μM) results in a concentration-dependent decrease in Aβ and APPsβ production in K695sw cells. FCCP inhibits processing of wild-type APP. FCCP does not alter cellular ATP levels at any of the concentrations measured. The effects of FCCP on APP catabolism are independent of secondary effects on oxidative phosphorylation or the result of reduced cell viability in K695sw cells. FCCP (5 μM or 500 nM), baf A1, and NH4Cl induce changes in Tf-Tx and Tf-F cellular fluorescence in K695 cells. FCCP (200 nM) protects and enhances the follicle integrity in cat ovarian tissue during short-term in vitro culture. But FCCP does not appear to exert a beneficial or detrimental effect during ovarian tissue cryopreservation.
体外实验

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体内实验

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同义词

Trifluoromethoxy carbonylcyanide phenylhydrazone
通路

Others
靶点

Other Targets
受体

Others
研究领域

Cancer
适应症

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1.HEYTLER PG et al. A new class of uncoupling agents--carbonyl cyanide phenylhydrazones. Biochem Biophys Res Commun. 1962 May 4;7:272-5.

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