021-51111890
购物车（）
sales@molnova.cn
AY-9944
CAS No. 366-93-8
AY-9944 ( AY9944 )
产品货号. M14261 CAS No. 366-93-8
AY-9944 是一种胆固醇生物合成抑制剂，靶向 7-脱氢胆固醇 Δ7-还原酶 (DHCR7) (IC50=13 nM)。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥497 | 有现货 |
|
| 5MG | ￥787 | 有现货 |
|
| 10MG | ￥1311 | 有现货 |
|
| 25MG | ￥2678 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称AY-9944
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述AY-9944 是一种胆固醇生物合成抑制剂，靶向 7-脱氢胆固醇 Δ7-还原酶 (DHCR7) (IC50=13 nM)。
-
产品描述AY-9944 is a cholesterol biosynthesis inhibitor that targets the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme (IC50=13 nM), attenuates of Smoothened-dependent and -independent Hh signaling; has been used to recapitulate phenotypes of Smith-Lemli-Opitz syndrome in animal model.
-
体外实验Cell Viability Assay Cell Line:Human foreskin keratinocytes Concentration:1 μg/mL Incubation Time:15 hours Result:Inhibited the synthesis of cholesterol and desmosterol, but increased 7-dehydrocholesterol and zymosterol synthesis.
-
体内实验Animal Model:Long–Evans hooded rats.Dosage:7.5 mg/kg Administration:Subcutaneous injection; 7.5 mg/kg every 6 days once; from postnatal day 2 to postnatal day 20 Result:Reduced brain cholesterol and increased 7-dehydrocholesterol in all brain regions of rats till the treatment stopped for 400 days and showed a more severe effect on the change of sterols in plasma and liver of female rats.
-
同义词AY9944
-
通路GPCR/G Protein
-
靶点Hedgehog (Hh)
-
受体Hedgehog (Hh)
-
研究领域——
-
适应症——
化学信息
-
CAS Number366-93-8
-
分子量464.3
-
分子式C22H28Cl2N2 ? 2HCl
-
纯度>98% (HPLC)
-
溶解度In Vitro:?DMSO : 5 mg/mL (10.77 mM)
-
SMILESClC1=CC=CC=C1CNC[C@H]2CC[C@H](CNCC3=CC=CC=C3Cl)CC2.Cl.Cl
-
化学全称trans-N,N-bis[2-Chlorophenylmethyl]-1,4-cyclohexanedimethanamine dihydrochloride
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Horlick L. J Lipid Res. 1966 Jan;7(1):116-21.
2. Lauth M, et al. Mol Pharmacol. 2010 Sep;78(3):486-96.
3. Xu L, et al. J Lipid Res. 2011 Oct;52(10):1810-20.
