Etoposide

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

依托泊苷是鬼臼毒素的半合成衍生物，通过拓扑异构酶 II 抑制活性来抑制 DNA 合成。

Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity.

Cell Viability Assay Cell Line:HCT116 FBXW+/+, FBXW-/- and p53-/- cells Concentration:0.025 μM, 0.05 μM, 0.075 μM, 0.1 μM, 0.2 μM, 0.4 μM, 0.6 μM, 0.8 μM, 1 μM Incubation Time:72 hours Result:Inhibits HCT116 FBXW+/+p>, FBXW-/- and p53-/- cell growth as a concentration manner.Western Blot Analysis Cell Line:HCT116 FBXW7+/+ or FBXW7-/- cells Concentration:25 μM Incubation Time:6 hours Result:Exhibited that the recovery of p53 levels after DNA damage is mediated by FBXW7.

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EPE | NSC 141540 | VP-16-123

Cell Cycle/DNA Damage

Topoisomerase

Topo II

Cancer

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33419-42-0

588.56

C29H32O13

>98% (HPLC)

DMSO: 100 mg/mL (169.9 mM)

O=C1OC[C@]2([H])C(O[C@H]3[C@H](O)[C@@H](O)[C@]4([H])O[C@H](C)OC[C@@]4([H])O3)C5=C(C=C6OCOC6=C5)[C@@H](C7=CC(OC)=C(O)C(OC)=C7)[C@]21[H]

(5R,5aR,8aR)-9-(((2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methylhexahydropyrano[3,2-d][1,3]dioxin-6-yl)oxy)-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one

(-20℃)

With Ice Pack

≥ 2 years